{"id":14990,"date":"2017-05-21T12:00:11","date_gmt":"2017-05-21T17:00:11","guid":{"rendered":"http:\/\/panamaextrema.com\/pe\/?p=14990"},"modified":"2017-05-18T10:02:38","modified_gmt":"2017-05-18T15:02:38","slug":"logran-transformar-celulas-madre-celulas-sanguineas-primordiales","status":"publish","type":"post","link":"https:\/\/panamaextrema.com\/pe\/logran-transformar-celulas-madre-celulas-sanguineas-primordiales\/","title":{"rendered":"Logran transformar c\u00e9lulas madre en c\u00e9lulas sangu\u00edneas primordiales"},"content":{"rendered":"<p><strong><\/strong><\/p>\n<p>Despu\u00e9s de 20 a\u00f1os intent\u00e1ndolo, dos equipos de cient\u00edficos han conseguido con dos recetas distintas <b>transformar c\u00e9lulas madre en c\u00e9lulas sangu\u00edneas primordiales<\/b> (hematopoy\u00e9ticas) capaces de producir la mayor\u00eda de los tejidos.&nbsp;<\/p>\n<p>Este trabajo<b> ofrece esperanza a las personas con leucemia y otros trastornos de la sangre <\/b>que necesitan trasplantes de m\u00e9dula \u00f3sea, pero en los que no es posible encontrar un donante compatible. Gracias a este avance,<b> estos pacientes podr\u00edan recibir versiones cultivadas en laboratorio de sus propias c\u00e9lulas sanas<\/b>.<\/p>\n<blockquote><p>\u00abEstamos tentadoramente cerca de generar c\u00e9lulas madre de sangre humana fidedigna en laboratorio. <b>Este trabajo es la culminaci\u00f3n de m\u00e1s de 20 a\u00f1os de lucha<\/b>\u00ab, explica George Daley, l\u00edder del trabajo y director de un laboratorio de investigaci\u00f3n en el Programa de C\u00e9lulas Madre del Hospital Infantil de Boston (EE. UU.), as\u00ed como decano de la Escuela de Medicina de Harvard.<\/p><\/blockquote>\n<p class=\"\">&nbsp;<\/p>\n<p class=\"\">El primer equipo, del <b>Hospital Infantil de Boston<\/b>, combin\u00f3 dos enfoques anteriores: <b>exponer c\u00e9lulas madre pluripotentes humanas a se\u00f1ales qu\u00edmicas <\/b>que las orientaron para diferenciarse en c\u00e9lulas y tejidos especializados durante el desarrollo embrionario normal para despu\u00e9s a\u00f1adirles factores reguladores gen\u00e9ticos para incitar al endotelio hemog\u00e9nico hacia un estado formador de sangre.<\/p>\n<p>Con 5 factores de transcripci\u00f3n clave, c<b>onsiguieron crear las c\u00e9lulas madre de la sangre<\/b>. El proceso concluy\u00f3 con el trasplante de c\u00e9lulas endoteliales hemog\u00e9nicas modificadas gen\u00e9ticamente a un grupo de roedores.&nbsp;<\/p>\n<p class=\"\">El segundo equipo de investigaci\u00f3n, procedente del <b>Weill Cornell Medicine<\/b> de Nueva York (EE. UU.) <b>emple\u00f3 c\u00e9lulas endoteliales de rat\u00f3n adulto<\/b>. Alteraron los niveles de los factores de transcripci\u00f3n para impulsar su transici\u00f3n a c\u00e9lulas madre de sangre, que se formaron en una capa de c\u00e9lulas endoteliales fetales para confirmar sus propiedades.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Despu\u00e9s de 20 a\u00f1os intent\u00e1ndolo, dos equipos de cient\u00edficos han conseguido con dos recetas distintas transformar c\u00e9lulas madre en c\u00e9lulas sangu\u00edneas primordiales (hematopoy\u00e9ticas) capaces de producir la mayor\u00eda de los tejidos.&nbsp; Este trabajo ofrece esperanza a las personas con leucemia y otros trastornos de la sangre que necesitan trasplantes de m\u00e9dula \u00f3sea, pero en los &hellip;<\/p>\n","protected":false},"author":2,"featured_media":14991,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[40],"tags":[],"class_list":["post-14990","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-noticias"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Logran transformar c\u00e9lulas madre en c\u00e9lulas sangu\u00edneas primordiales &#171; 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